Two Colorado studies find resistance mechanisms in ALK+ and ROS1+ cancers

In one of 12 ROS1+ samples and 15 of 43 ALK+ samples, new kinases had been altered to allow treatment resistance. However, ‘we found a lot of stuff besides kinase mutations,’ a researcher says. ‘What we’re trying to say is that resistance happens in a lot of different ways and we need to be thinking about all the genetic and non-genetic changes that can occur.’
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