Immunotherapy combo achieves reservoir shrinkage in HIV model

Stimulating immune cells with two cancer immunotherapies together can shrink the size of the viral ‘reservoir’ in SIV-infected non-human primates treated with antiviral drugs. The findings have important implications for the quest to cure HIV, because reservoir shrinkage has not been achieved consistently before. However, the combination treatment does not prevent or delay viral rebound once antiviral drugs are stopped — illustrating how difficult achieving a cure will be.
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