Empowering mucosal healing with an engineered probiotic

Harvard Wyss Institute researchers developed a living material approach that uses a strain of genetically engineered E.coli Nissle bacteria as a locally acting probiotic. The engineered bacteria produce a network of nanofibers that directly binds to mucus to fill inflamed areas like a patch, shielding them from gut microbes and environmental factors. This probiotic-based therapeutic strategy protected mice against the effects of colitis induced by a chemical agent and promoted mucosal healing.
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