Clarifying the role of CHOP/GADD153 in cell death

In the May 2016 Nature Communications, investigators at the Medical University of South Carolina report that CHOP/GADD153-dependent apoptosis is mediated by the micro-RNA miR-216b. Previously, CHOP was known to mediate cell death but how precisely it did so remained unclear. Illuminating the pathway through which CHOP contributes to cell death provides vital information for translating new, small-molecule drugs into effective, real-world therapies by identifying biomarker targets and helping predict patient responses to treatment.
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