Accepted or rejected? Uncovering how fate of B cell is determined

Osaka University-centered researchers identify the plasma cell-prone B cells in the light zone of germinal centers. Higher expression of the proteins ICAM-1 and SLAM in those cells facilitates more stable contacts with Tfh cells, suggesting that strength of Tfh-GC B cell interaction critically regulates formation of plasma cell precursors. The findings serve as important information for the development of effective vaccines against viral infection.
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