A mechanical trigger for toxic tumor therapy

Cell-killing chemotherapies are designed to shrink cancerous tumors by accumulating in their ill-formed blood and lymph vessels, delivering a toxic dose to the cancer cells. A team of researchers at the Wyss Institute has developed a new drug delivery platform that uses safe, low-energy ultrasound waves to trigger aggregates of chemotherapy-containing nanoparticles to break apart precisely at tumor sites, resulting in dramatically improved targeting efficacy and toxicity profile in mouse models of breast cancer.
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